Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity
We are delighted to announce the publication of this paper, in the journal PNAS. Abstract Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a […]
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I’ll Take That to Go: Big Data Bags and Minimal Identifiers for Exchange of Large, Complex Datasets
This paper was presented at the IEEE International Conference on Big Data 2016. Abstract Big data workflows often require the assembly and exchange of complex, multi-element datasets. For example, in biomedical applications, the input to an analytic pipeline can be a dataset consisting thousands of images and genome sequences assembled from diverse repositories, requiring a […]
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Hear from our travel grant beneficiaries
For each of our BioExcel training events we make a limited number of travel bursaries available. We ask the beneficiaries of the BioExcel travel grant to write a blog post for us, either about their experiences at the course, their research interests (in layman’s terms) or a relevant scientific topic. THE POWER OF KNOWLEDGE […]
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Developing a Benchmark Suite for Semantic Web Data from Existing Workflows
This paper was presented at the BLINK 2016 Workshop on Benchmarking Linked Data. Abstract This paper presents work in progress towards developing a new benchmark for federated query processing systems. Unlike other popular benchmarks, our queryset is not driven by technical evaluation, but is derived from workflows established by the pharmacology community. The value of this […]
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Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop
We are pleased to announce the publication of this paper, in the journal Structure. Abstract Hepatitis C virus (HCV) enters into human hepatocytes via tetraspanin hCD81. HCV glycoprotein E2 recognizes the “head” subdomain of the large extracellular loop (LEL) of CD81 (hCD81LEL), but the precise mechanism of virus cell attachment and entry remains elusive. Here, […]
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